drlorisnyder

Biology Week Topic: Genomics, Earthquakes, and Cholera

Bacterial Genetics and Genomics book Discussion Topic: Chapter 11, question 14 Although I had planned to continue to work through the Discussion Topics from Bacterial Genetics and Genomics that are all related to the investigations in bacterial genetics and genomics using bioinformatics tools can be conducted outside of the lab, October here in the UKContinue reading “Biology Week Topic: Genomics, Earthquakes, and Cholera”

Bacterial genomes, then and now

Bacterial Genetics and Genomics book Discussion Topic: Chapter 17, question 13 The publications of the first bacterial genome sequences were 25 years ago. The technology has come a long way since then, both in the lab and computationally. One of the first bacterial genome sequencing projects started was one undertaken to sequence the complete EscherichiaContinue reading “Bacterial genomes, then and now”

Research and planning outside of the lab: working with restriction enzymes.

Bacterial Genetics and Genomics book Discussion Topic: Chapter 16, question 15 For this blog, I have decided to look at the Discussion Topic from Bacterial Genetics and Genomics, Chapter 16, question 15, which discusses restriction enzymes and encourages us to try finding digest sites for these enzymes ourselves in a gene of interest, using on-lineContinue reading “Research and planning outside of the lab: working with restriction enzymes.”

More research outside of the lab, protein structure predictions

Bacterial Genetics and Genomics book Discussion Topic: Chapter 16, question 14 Continuing on from the blog post last month, I am keeping on the topic of research that can be done at home, or at the computer, without needing to do experiments in the lab. Quite a lot of genetics and genomics research today involvesContinue reading “More research outside of the lab, protein structure predictions”

Doing research and making discoveries outside of the lab

Investigations in bacterial genetics and genomics using bioinformatics tools can be conducted outside of the lab. This means that so long as you have an internet connection, you can do meaningful research and make meaningful discoveries.

Antibiotic delivery to the site of infection

Repurposing of antibiotics and thinking about them in new ways in which we can use them to fight infections are important points for discussion. Understanding bacterial genetics and genomics gives us insights into biofilms and antimicrobial susceptibilities that can drive ongoing and future research.

Ribozymes from LUCA to today

Bacterial Genetics and Genomics book Discussion Topic: Chapter 1, question 13 In honor of today, the day my book is released to the world, I have decided to blog on the topic of the very first Discussion Topic in the book. This relates to the Last Universal Common Ancestor (LUCA) before what we recognize nowContinue reading “Ribozymes from LUCA to today”

Tackling annotation errors to find the pangenome with Panaroo

Bacterial Genetics and Genomics book Discussion Topic: Chapter 12, question 15 I saw a Tweet about a paper on pangenome analysis and decided to read it. It is on bioRxiv, the preprint server for biology (https://www.biorxiv.org/). The papers here aren’t peer reviewed, like to you would find in typical journals, so when you read somethingContinue reading “Tackling annotation errors to find the pangenome with Panaroo”

Genome sequencing in the palm of your hand

Bacterial Genetics and Genomics book Discussion Topic: Chapter 11, question 14. Last week I attended the Festival of Genomics in London. These are excellent events, run by Front Line Genomics and due to the support of many sponsors, they are free to attend. Going to the Festival of Genomics is an excellent opportunity to hearContinue reading “Genome sequencing in the palm of your hand”

The blog

Why write a blog? As my book went off to press, sequencing was in the news as it is being applied to the coronavirus outbreak. New and exciting events like this are not captured in the book, but can be included in a blog. Yes, viruses like the coronavirus are outside of the scope ofContinue reading “The blog”