Harnessing aptamers for rapid detection of bacteria and antibiotics in our food.

Bacterial Genetics and Genomics book Discussion Topic: Chapter 4, question 14 The specificity of antibody binding has been exploited for many years in a variety of technologies. Although perhaps less famous, aptamers also have high binding specificity for their targets and, being made of RNA or DNA rather than protein, are much smaller in size,Continue reading “Harnessing aptamers for rapid detection of bacteria and antibiotics in our food.”

Merging two concepts: finding genes that are both essential and core

Bacterial Genetics and Genomics book Discussion Topic: Chapter 3, question 13 One of the concepts that is discussed in Bacterial Genetics and Genomics is the difference between essential genes and accessory genes. The essential genes are those that are required for the bacteria to live and the accessory genes allow it to do something elseContinue reading “Merging two concepts: finding genes that are both essential and core”

Bacteria breaking the rules – again. This time, its coupled transcription – translation.

Bacterial Genetics and Genomics book Discussion Topic: Chapter 2, question 14 It has long been a defining difference that bacterial cells, like E. coli, have coupled transcription-translation and eukaryotic cells, like animals and plants, make their mRNA in the nucleus and their proteins in the cytoplasm. This is mostly the case. Mammals did break theContinue reading “Bacteria breaking the rules – again. This time, its coupled transcription – translation.”

Bacterial genomes, then and now

Bacterial Genetics and Genomics book Discussion Topic: Chapter 17, question 13 The publications of the first bacterial genome sequences were 25 years ago. The technology has come a long way since then, both in the lab and computationally. One of the first bacterial genome sequencing projects started was one undertaken to sequence the complete EscherichiaContinue reading “Bacterial genomes, then and now”

Doing research and making discoveries outside of the lab

Investigations in bacterial genetics and genomics using bioinformatics tools can be conducted outside of the lab. This means that so long as you have an internet connection, you can do meaningful research and make meaningful discoveries.

Antibiotic delivery to the site of infection

Repurposing of antibiotics and thinking about them in new ways in which we can use them to fight infections are important points for discussion. Understanding bacterial genetics and genomics gives us insights into biofilms and antimicrobial susceptibilities that can drive ongoing and future research.

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