What does a two-component regulator do when it isn’t phosphorylated?
Bacterial Genetics and Genomics, Chapter 8, Discussion topic 2. As described in Chapter 8 of Bacterial Genetics and Genomics, a two-component regulatory system has a sensory protein in the membrane that autophorphorylates when triggered by its sensory signal and a regulatory protein that is phosphorylated to do its job adjusting gene expression. In this way, something…
A single amino acid change can have a big impact on the bacteria.
Bacterial Genetics and Genomics, Chapter 7, Discussion topic 2. It doesn’t take much to alter the sequence of a protein. Whilst some single nucleotide changes to the DNA sequence can be tolerated, others cause the gene to encode a different amino acid in the protein. Again, some of these changes to the amino acid sequence can…
Pathogens at low temperature and antimicrobials.
Bacterial Genetics and Genomics, Chapter 6, Discussion topic 2 and 3. Listeria monocytogenes and Escherichia coli are able to grow at low temperatures and from there be transmitted to humans and cause disease. Having antimicrobials that can work at low temperatures is important to breaking the transmission chain, particularly from food. However, most experiments on…
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Bacterial Genetics and Genomics, by Lori A. S. Snyder 